PRODUCTS AND SERVICES TO FISH

 

VETCARE
DIAGNOSTICS - VACCINES - DISINFECTANTS
- NUTRACEUTICALS - MEDICINES

MEDICATIONS

AQUAHEALTH
VETERINARY SERVICES - FARM HYGIENE FISH VACCINATION - CONSULTANCY

OXYTETRACYCLINE
(OTC)

Characteristics:

The tetracyclines are broad spectrum bacteriostatic drugs acting within the bacterial cell and blocking the ribosomal functions as regards protein synthesis, such as building of enzymes. They comprise either natural fermentation products or semi-synthetic derivatives. Oxytetracycline (OTC) belongs to the natural tetracyclines and is widely used in aquaculture. Despite its long usage in aquaculture world-wide as well as in the Mediterranean fish farming, it is a potent antibiotic against the most common bacterial fish pathogens, both Gram negative and Gram positive as well as against rickettsiae. In addition, it is relatively cheaper than other broad-spectrum antibacterial drugs.

Composition of OTC compounds:

OTC compounds for veterinary use in aquaculture comprise 50% water soluble feed premixes in powdered form. 1g of such powders contains 500mg Oxytetracycline HCl (about 500mg oxytetracycline base) bound to a water soluble agent.

Indications:

OTC compounds are wide spectrum antibacterials against Gram negative and Gram positive fish pathogenic bacteria, indicated for the treatment of fish systemic bacterial infections caused by Aeromonas spp., Vibrio spp., Photobacterium spp., Yersinia spp., Pseudomonas spp., Staphylococcus spp., Micrococcus spp., Enterococcus spp. and many others.

Prior to administration, always investigate the sensitivity/resistance of bacteria (antibiogramme).

Precautions:

Adverse effects of OTC on fish comprise immunosuppression (reduced cellular and humoral responses as well as reduced immunological memory) and reduction in lymphocyte, monocyte and erythrocyte counts. Thus, administering OTC compounds to fish prior or post vaccinations is not recommended.

OTC should not be administered together with compounds containing quinolones (oxolinic acid, flumequine) nitrofurans, potentiated sulfonamides (e.g. Tribrissen, Optiprime), or penicillins (ampicillin, amoxicillin). In addition, OTC should not be administered to fish for more than 12 consecutive days without at least a few days break.

Administration and dosage:

OTC 50% premixes are orally administered via compounding with the fish feed. They may be mixed with fish oil, which is then top-dressed onto pre-pelleted diets. Alternatively, the premixes may be diluted in some water, which is then sprayed onto the feed. After the feed dries in air, some fish oil may be used for top coating.

Daily feeding rate

Fish biomass fed 25kg of feed

OTC 50% premix /25kg feed

0.5%

5,000 kg

1,000 g

1.0%

2,500 kg

500 g

1.5%

1,670 kg

334 g

2.0%

1,250 kg

250 g

Withdrawal period:

360 degree-days (21 days after the last administration at water temperature no less than 17° C).

Storage and packing:

OTC premixes are available often in 5kg plastic containers/tubs and in 20kg reinforced sacks. May be stored for up to 36 months in a dry, dark and cool (up to 25°C) environment.
Containers must be closed firmly after use.

 

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Copyright © Dr Panos Varvarigos

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Disclaimer:

Every effort has been made to ensure that the information in the notes and papers contained and linked herein is accurate until the date of last editing. It is based upon the accumulated personal experience of applied work in the field. The author cannot take responsibility for incorrect interpretation and any resulting consequences.

The contents may be used only as an educational guide and are not meant to become a stand-alone diagnostic tool or treatment manual or replace professional assistance.

 

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