PRODUCTS AND SERVICES TO FISH

 

VETCARE
DIAGNOSTICS - VACCINES - DISINFECTANTS
- NUTRACEUTICALS - MEDICINES

MEDICATIONS

AQUAHEALTH
VETERINARY SERVICES - FARM HYGIENE FISH VACCINATION - CONSULTANCY

OXOLINIC ACID
(OXA)

Characteristics:

Oxolinic acid is a true 4-quinolone, belonging to a group of chemically related synthetic antibacterial agents all being carboxylic acids. The sodium salt is soluble in water and suitable for use in aquaculture. The quinolones are bactericidal. They inhibit the bacterial enzyme DNA-gyrase resulting in breaks in the bacterial DNA coiling.

OXA is efficacious against Gram negative bacterial pathogens of fish. Administered orally, blended with the fish feed, it shows a high bioavailability and is widely used for the treatment of most fish systemic bacterial infections.

Composition of OXA compounds:

Water soluble fish feed premixes, either 24%, or 50% in powdered form, which contain 240g or 500g of oxolinic sodium salt per 1000g of premix powder respectively.

Indications:

Wide spectrum antibacterial against Gram negative fish pathogenic bacteria. It is potent for the treatment of fish bacterial systemic infections in aquaculture caused by Aeromonas spp., Vibrio spp., Photobacterium spp., Yersinia spp., Pseudomonas spp. and many others.

Always investigate the sensitivity/resistance of bacteria (antibiogramme) prior to administration.

Precautions:

OXA premixes should not be administered together with compounds containing oxytetracycline, other tetracyclines, nitrofurans, or sulfonamides. OXA should not be administered to fish for more than 10 consecutive days without a few days break.

Administration and dosage:

OXA premixes are orally administered via compounding with the fish feed. They may be mixed with fish oil, which is then top-dressed onto pre-pelleted diets. Alternatively, the premixes may be diluted in some water, which is then sprayed on the feed. After the feed dries in air, some fish oil may be used for top coating.

·         Recommended therapeutic dose of active OXA for marine farmed fish (Mediterranean): 60mg/kg of biomass/day (or 6g/100kg of biomas/day) continuously for 7-10 days

·         Respective dose for 24% powdered premix: 25g/100kg biomass/day (or 250g/1000kg biomass/day) continuously for 7-10 days

·         Respective dose for 50% powdered premix: 12g/100kg biomass/day (or 120g/1000kg biomass/day) continuously for 7-10 days

·        Recommended daily dosages of OXA premixes 24% and 50% compounded in 25 kg of fish feed (1 sack), according to the feeding rate (expressed as percentage of fish biomass):

Daily feeding rate

Fish biomass fed 25kg of feed

OXA 24% premix /25kg feed

OXA 50% premix /25kg feed

0.5%

5,000 kg

1,250 g

600 g

1.0%

2,500 kg

625 g

300 g

1.5%

1,670 kg

418 g

200 g

2.0%

1,250 kg

313 g

150 g

Withdrawal period:

150 degree-days (9 days after the last administration at water temperature no less than 17° C).

Storage and packing:

Distributed in 5kg reinforced packs. May be stored for up to 36 months in a dry, dark and cool (up to 25°C) environment. Close pack firmly after use.

 

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Copyright © Dr Panos Varvarigos

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Disclaimer:

Every effort has been made to ensure that the information in the notes and papers contained and linked herein is accurate until the date of last editing. It is based upon the accumulated personal experience of applied work in the field. The author cannot take responsibility for incorrect interpretation and any resulting consequences.

The contents may be used only as an educational guide and are not meant to become a stand-alone diagnostic tool or treatment manual or replace professional assistance.

 

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